Experimental thrombocytopenia and capillary ultrastructure

Experimental thrombocytopenia and capillary ultrastructure.

By David Shepro, H. E. Sweetman, and H. B. Hechtman R EDUCED circulating platelets or thrombocytopenia is associated frequently with a propensity for petechial and purpuric hemorrhages. This observation has led to the concept that platelets support vascular endothelium and maintain vascular integrity by a mechanism separate from hemostasis or vascular repair. ‘ 6 Experimental thrombocytopenic a...

Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions

BACKGROUND Sugar-protein glycocalyx coats healthy endothelium, but its ultrastructure is not well described. Our aim was to determine the three-dimensional ultrastructure of capillary endothelial glycocalyx in the heart, kidney, and liver, where capillaries are, respectively, continuous, fenestrated, and sinusoidal. METHODS Tissue samples were processed with lanthanum-containing alkaline fixa...

Thrombocytopenia in experimental trypanosomiasis.

The effect of experimental trypanosomiasis on coagulation was studied because a patient in this hospital with Rhodesian trypanosomiasis developed thrombocytopenia with disseminated intravascular coagulation. Rats injected intraperitoneally with this strain of Trypanosoma rhodesiense consistently developed trypanosomiasis and severe thrombocytopenia without changes in hematocrit or concentration...

Effects of endotoxin on pulmonary capillary permeability, ultrastructure, and surfactant.

Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes.

PURPOSE The goal of this ultrastructural study was to examine fiber cell shape and intercellular junctions during the early stages of fiber cell breakdown and edema in diabetic rabbit lenses. METHODS Lens abnormalities were recorded with a slit lamp. Between 6-10 mo after drug treatment, diabetic lenses and untreated control lenses were freshly enucleated and sectioned with a vibrating knife ...